Statistical similarities between transcriptomics and quantitative shotgun proteomics data.

@article{Pavelka2008StatisticalSB,
  title={Statistical similarities between transcriptomics and quantitative shotgun proteomics data.},
  author={Norman Pavelka and Marjorie L Fournier and Selene K Swanson and Mattia Pelizzola and Paola Ricciardi-Castagnoli and Laurence Florens and Michael P Washburn},
  journal={Molecular & cellular proteomics : MCP},
  year={2008},
  volume={7 4},
  pages={
          631-44
        }
}
If the large collection of microarray-specific statistical tools was applicable to the analysis of quantitative shotgun proteomics datasets, it would certainly foster an important advancement of proteomics research. Here we analyze two large multidimensional protein identification technology datasets, one containing eight replicates of the soluble fraction of a yeast whole-cell lysate and one containing nine replicates of a human immunoprecipitate, to test whether normalized spectral abundance… CONTINUE READING

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