Statistical significance of combinatorial regulations.

@article{Terada2013StatisticalSO,
  title={Statistical significance of combinatorial regulations.},
  author={Aika Terada and Mariko Okada-Hatakeyama and Koji Tsuda and Jun Sese},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 32},
  pages={
          12996-3001
        }
}
More than three transcription factors often work together to enable cells to respond to various signals. The detection of combinatorial regulation by multiple transcription factors, however, is not only computationally nontrivial but also extremely unlikely because of multiple testing correction. The exponential growth in the number of tests forces us to set a strict limit on the maximum arity. Here, we propose an efficient branch-and-bound algorithm called the "limitless arity multiple-testing… CONTINUE READING
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