Statistical properties of the NOAEL.

  title={Statistical properties of the NOAEL.},
  author={Wendy W Leisenring and Louise Ryan},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={15 2 Pt 1},
The use of the no observed adverse effect level (NOAEL) in setting allowable exposure levels for noncancer endpoints is a source of controversy. Based on computer simulations and empirical studies, several authors have criticized the use of the NOAEL in terms of its sensitivity to sample size and its high sampling variability from experiment to experiment. The purpose of this paper is to derive the statistical distribution of the NOAEL. Using Weibull models, we investigate the impact of the… CONTINUE READING