Statistical problems in assessing methods of medical diagnosis, with special reference to X-ray techniques.

  title={Statistical problems in assessing methods of medical diagnosis, with special reference to X-ray techniques.},
  author={Jacob Yerushalmy},
  journal={Public health reports},
  volume={62 40},
  • J. Yerushalmy
  • Published 3 October 1947
  • Medicine
  • Public health reports
The leading article in this issue, "Statistical Problems in Assessing Methods of Medical Diagnosis with Special Reference to X-ray Techniques," by Jacob Yerushalmy, is an extension of a stuidy which originally was published in the Journal of the American Medical Association.1 This study is regarded as a striking contribution to knowledge in the field of roentgenology and has given rise, in some quarters, to a dissent not unrelated to apprehension. Upon first consideration, theconclusions of the… 

Tables from this paper

Diagnostic studies as multivariable, prediction research

The use of quantitative statistical models in diagnostic research is currently unfortunately dictated by mathematical, quantitative models, often ignoring the practitioners' judgement, however, it is believed that these quantitative models are necessary in order to estimate the true, independent (or added) value of a test, just as they were necessary in aetiological studies to estimates the independent association of a particular exposure and the occurrence of a specific outcome.

Statistical methods in epidemiology. VIII. On the use of likelihood ratios for diagnostic testing with an application to general practice

The naive Bayes' discriminant has proved to be the most durable of statistical discriminants in medical diagnosis and remains a popular choice as a diagnostic aid despite a concern about independence.

The reliability of chest roentgenography and its clinical implications.

It is no doubt superfluous to state that, in spite of these difficult problems of interpretation, serial roentgenograms are among the most valuable criteria for assessing the course of disease in a patient with pulmonary tuberculosis.

The Poor Quality of Early Evaluations of MRI

The implication that sensitivity, specificity, and receiver-operating characteristic analysis provide a uniquely proper and complete format for the evaluation of radiographic results and that their underutilization by the radiology community implies ignorance about or lack of concern for proper analysis is disagreed with.

Evaluation of diagnostic tests when there is no gold standard. A review of methods.

A classification of methods to evaluate medical tests when there is no gold standard is generated and the majority of methods try to impute, adjust or construct a reference standard in an effort to obtain the familiar diagnostic accuracy statistics, such as sensitivity and specificity.

A decision theoretical comparison of three procedures of screening for a single disease

Three ways of using screening data are examined: the single test, with positive or negative indication; the profile, an array of estimates of levels for each of a set of relevant factors; and the index, a single composite of weighted factors.

Advances in statistical methodology for diagnostic medicine in the 1980's.

  • C. Begg
  • Medicine
    Statistics in medicine
  • 1991
There is a sentiment that well-designed, prospective trials are required to provide credible information on the accuracy of diagnostic technologies, and so a consensus on methodological standards is needed, paralleling the earlier development of such standards in clinical trials and epidemiology.

A study of variability in the interpretation of chest x-rays in the detection of lung cancer.

An estimate of the variability in the interpretation of chest X-rays by radiologists is obtained and indicates the need for having 2 radiologists read X- rays independently in surveys in order to maximize the yield of suspect cases.

A review of statistical methods in the analysis of data arising from observer reliability studies (Part II)

Summary This paper reviews research situations in medicine, epidemiology and psychiatry, in psychological measurement and testing, and in sample surveys in which the observer(rater or interviewer)

Estimates of Sensitivity and Specificity in a Multistage Screen for Medical Diagnosis

A multistage screen is used when k different medical tests are available to the physician, and a patient is subjected to Test j only if Test j1 yielded a positive result, 2 j < k. In observational


Plague infection has been reported proved in fleas from rodents