Statistical optimization of process variables for the large-scale production of Metarhizium anisopliae conidiospores in solid-state fermentation.

@article{Prakash2008StatisticalOO,
  title={Statistical optimization of process variables for the large-scale production of Metarhizium anisopliae conidiospores in solid-state fermentation.},
  author={G V S Bhanu Prakash and Vani Padmaja and R R Siva Kiran},
  journal={Bioresource technology},
  year={2008},
  volume={99 6},
  pages={
          1530-7
        }
}
Optimization of conidial production was achieved by response surface methodology (RSM), a powerful mathematical approach widely applied in the optimization of fermentation process, using the three substrates; rice, barley and sorghum at variable pH, moisture content and yeast extract concentrations. These three factors were found to be important, affecting Metarhizium anisopliae spore production. A 2(3) full factorial central composite design and RSM were applied to determine the optimal… CONTINUE READING

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