Statistical models for biphasic dose-response relationships (hormesis) in toxicological studies
@inproceedings{Nweke2017StatisticalMF, title={Statistical models for biphasic dose-response relationships (hormesis) in toxicological studies}, author={Christian Okechukwu Nweke and Chukwudi Ogbonna}, year={2017} }
The dose-response phenomenon characterized by low dose stimulation and high dose toxicity has been reawakened after a long period of marginalization. This phenomenon termed hormesis is induced by biological, physical and chemical agents and occurs in all groups of living things including whole plants and animals, microorganisms, cells and tissues. Hormesis has attracted increased interest among toxicologists from diverse disciplines, resulting to emergence of new scientific tools for its study…
18 Citations
Statistical modeling of effective doses in hormetic dose-response relationships by reparameterization of a bilogistic model for inverted U-shaped curves
- Environmental ScienceAfrican Journal of Biotechnology
- 2021
Hormesis is a biphasic dose (concentration)-response phenomenon characterized by low dose stimulatory and high dose inhibitory effects exerted by stressors on living organisms. Recently, there has…
Statistical modeling of hormesis quantities in inverted U-shaped dose-response relationships by reparameterization of a bilogistic model
- BiologyJournal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering
- 2022
Further extensions of the bilogistic model of Beckon and coworkers are presented to determine the toxic potency and hormetic dose zone by estimating two effective doses simultaneously and to provide versatile statistical tools for quantitatively exploring a variety of biphasic dose-response curves.
A Universal Delayed Difference Model Fitting Dose-response Curves
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A novel dynamic model (DRDM) for fitting to various types of dose-response curves, which can reflect the dynamic trend of the population growth compared with traditional static dose- response models is proposed and confirmed that the DRDM provides an ideal description of various dose- Response observations and it can be used to fit a wide range of doses-response data sets.
Biphasic hCAR Inhibition-Activation by Two Aminoazo Liver Carcinogens
- Biology
- 2018
The pronounced biphasic hCAR response pattern observed for 4-aminoazobenzene is particularly noteworthy insofar as it was identified with statistical power that exceeds that of most if not all other receptor-mediated bipwasic cellular responses to any single-chemical exposure reported to date.
New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in Vitro Nanoparticle Cytotoxicity
- BiologyDose-response : a publication of International Hormesis Society
- 2021
Spherical selenium-oxide and copper-oxide nanoparticles were found to be cytotoxic for human fibroblast-like cells in vitro, as judged by decreased ATP-dependent luminescence and it was demonstrated that combined toxicity of SeO-NP and CuO- NP is of different types depending on the outcome.
The various dose-dependent effect of selenium oxide and copper oxide nanoparticles in vitro and application of the hormesis paradigm
- BiologyHygiene and sanitation
- 2021
The general rule is the variability of the dose-response dependence types manifested in different cytotoxic effects of nanoparticles, as judged by a decrease in ATP-dependent luminescence.
Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations
- MedicineDose-response : a publication of International Hormesis Society
- 2020
Data analysis using a response surface linear model with a cross-term provided new support to the previously established postulate that a diversity of types of joint action characteristic of one and the same pair of damaging agents is one of the important assertions of the general theory of combined toxicity.
ON THE MEANING OF THE TERM «HORMESIS» AND ITS PLACE IN THE GENERAL THEORY OF THE DEPENDENCE OF THE BODY’S RESPONSE TO POTENTIALLY HARMFUL EFFECTS ON ITS STRENGTH
- Medicine
- 2020
Evidence-based analysis involving response surface linear model as well as a cross term acknowledged a new support to the formerly inflexible rule stating that the diversity kinds of combined action, typical for the same damaging agents’ pair is of the fundamental propositions in the general theory of combined toxicity.
On an extended understanding of the term "hormesis" for denoting alternating directions of the organism's response to increasing adverse exposures.
- PhysicsToxicology
- 2020
DRomics: A Turnkey Tool to Support the Use of the Dose-Response Framework for Omics Data in Ecological Risk Assessment.
- BiologyEnvironmental science & technology
- 2018
An open source tool which identifies the best model for concentration-response curve description after elimination of molecular responses with no concentration-dependency and/or high variability, and provides restitution for a table of results that can be directly used to perform ERA approaches.
References
SHOWING 1-10 OF 87 REFERENCES
The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview.
- Biology, Environmental ScienceToxicology and applied pharmacology
- 2005
Modeling Effective Dosages in Hormetic Dose-Response Studies
- BiologyPloS one
- 2012
The study showed that hormetic dose responses can take on many shapes and that this diversity can not be captured by a single model without risking considerable misinterpretation, and that the conclusions drawn depending on the model used may diverge considerably when using an improper hormetic model especially regarding effective dosages quantifying hormesis.
Improved empirical models describing hormesis
- Environmental ScienceEnvironmental toxicology and chemistry
- 2005
The new model is shown to be far more robust than previous models, both in terms of variation in data and in terms in describing hormetic effects ranging from small effects of a 10% increase in response up to effects of an almost 100% increaseIn response.
Statistical Tests for Hormesis and Effective Dosages in Herbicide Dose Response
- Chemistry
- 1999
The log-logistic model is a popular candidate for modeling dose response in agronomy. One of its limitations is monotonicity: the response is either continuously increasing or decreasing with changes…
Modeling non-monotonic dose-response relationships: model evaluation and hormetic quantities exploration.
- Environmental ScienceEcotoxicology and environmental safety
- 2013
Hormesis in mixtures -- can it be predicted?
- Chemistry, MedicineThe Science of the total environment
- 2008
A general approach to modeling biphasic relationships.
- BiologyEnvironmental science & technology
- 2008
A simple, general, biologically reasonable modeling approach is suggested leading to a family of mathematical models that combine log-logistic functions: at least one for the upslope and one forthe downslope of the biphasic relationship.
Hormesis: a highly generalizable and reproducible phenomenon with important implications for risk assessment.
- Environmental ScienceRisk analysis : an official publication of the Society for Risk Analysis
- 1999
The present analysis suggests that hormesis is a reproducible and generalizable biological phenomenon and is a fundamental component of many, if not most, dose-response relationships.
Novel approach to predicting hormetic effects of antibiotic mixtures on Vibrio fischeri.
- Chemistry, MedicineChemosphere
- 2013