Statistical model for fetal death, fetal weight, and malformation in developmental toxicity studies.

@article{Catalano1993StatisticalMF,
  title={Statistical model for fetal death, fetal weight, and malformation in developmental toxicity studies.},
  author={Paul J. Catalano and Daniel O Scharfstein and Louise M.. Ryan and Carole A. Kimmel and Gary L. Kimmel},
  journal={Teratology},
  year={1993},
  volume={47 4},
  pages={281-90}
}
The purpose of this paper is to present a statistical model for analyzing the joint effects of exposure on fetal death, fetal weight, and malformation in a developmental toxicity study. In addition to allowing for the usual litter effect, the model allows for correlations between different outcomes measured on the same fetus. Fitting the model requires first focusing on non-live outcomes by modeling the probability of fetal death or resorption as a function of dose. Then outcomes among live… CONTINUE READING
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