Statistical methods for studying disease subtype heterogeneity.

@article{Wang2016StatisticalMF,
  title={Statistical methods for studying disease subtype heterogeneity.},
  author={Molin Wang and Donna Spiegelman and Aya Kuchiba and Paul Lochhead and Sehee Kim and Andrew T. Chan and Elizabeth M Poole and Rulla M. Tamimi and Shelley S Tworoger and Edward L. Giovannucci and Bernard A Rosner and Shuji Ogino},
  journal={Statistics in medicine},
  year={2016},
  volume={35 5},
  pages={
          782-800
        }
}
A fundamental goal of epidemiologic research is to investigate the relationship between exposures and disease risk. Cases of the disease are often considered a single outcome and assumed to share a common etiology. However, evidence indicates that many human diseases arise and evolve through a range of heterogeneous molecular pathologic processes, influenced by diverse exposures. Pathogenic heterogeneity has been considered in various neoplasms such as colorectal, lung, prostate, and breast… CONTINUE READING
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