Statistical methods for assessment of added usefulness of new biomarkers.

  title={Statistical methods for assessment of added usefulness of new biomarkers.},
  author={Michael J. Pencina and Ralph B. D'Agostino and Ramachandran S. Vasan},
  journal={Clinical chemistry and laboratory medicine},
  volume={48 12},
The discovery and development of new biomarkers continues to be an exciting and promising field. Improvement in prediction of risk of developing disease is one of the key motivations in these pursuits. Appropriate statistical measures are necessary for drawing meaningful conclusions about the clinical usefulness of these new markers. In this review, we present several novel metrics proposed to serve this purpose. We use reclassification tables constructed on the basis of clinically meaningful… CONTINUE READING
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