Statistical methodology for recurrent events, with application to major trials in heart failure

@inproceedings{Rogers2013StatisticalMF,
  title={Statistical methodology for recurrent events, with application to major trials in heart failure},
  author={Jennifer Kathleen Rogers and Stuart J. Pocock},
  year={2013}
}
Composite outcomes are frequently adopted as primary endpoints in clinical trials as they consider fatal and non-fatal consequences of the disease under study and lead to higher event rates. Such analyses of time to first event are suboptimal for a chronic disease such as heart failure, characterised by recurrent hospitalisations, as information on repeats is ignored. We present a comparison of methods of analysing data on repeat hospitalisations, using data from major trials in heart failure… CONTINUE READING
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