Statistical method for analysis of the disease curve in animals with experimental autoimmune encephalomyelitis.

@article{Lee2003StatisticalMF,
  title={Statistical method for analysis of the disease curve in animals with experimental autoimmune encephalomyelitis.},
  author={Yonghee Lee and Bin Zhu and Claudine M Pulicicchio and Kathleen McMonagle-Strucko and Joseph G. Wettstein and Dennis Cosmatos},
  journal={Journal of biopharmaceutical statistics},
  year={2003},
  volume={13 1},
  pages={141-58}
}
Experimental autoimmune encephalomyelitis (EAE) is a procedure used in the laboratory to examine drugs that may have utility in treating multiple sclerosis (MS). The problem of modeling the disease curve in animals with EAE is studied. The classification of animals after each experiment is considered and the chi-square test is proposed to test a homogeneity between treatment groups. A mixture type of nonlinear mixed-effects model with repeated measurements is considered, assuming that the onset… CONTINUE READING