Statistical-mechanical lattice models for protein-DNA binding in chromatin.

@article{Teif2010StatisticalmechanicalLM,
  title={Statistical-mechanical lattice models for protein-DNA binding in chromatin.},
  author={Vladimir B. Teif and Karsten Rippe},
  journal={Journal of physics. Condensed matter : an Institute of Physics journal},
  year={2010},
  volume={22 41},
  pages={
          414105
        }
}
  • V. B. Teif, K. Rippe
  • Published 2010
  • Chemistry, Medicine, Physics, Biology
  • Journal of physics. Condensed matter : an Institute of Physics journal
Statistical-mechanical lattice models for protein-DNA binding are well established as a method to describe complex ligand binding equilibria measured in vitro with purified DNA and protein components. Recently, a new field of applications has opened up for this approach since it has become possible to experimentally quantify genome-wide protein occupancies in relation to the DNA sequence. In particular, the organization of the eukaryotic genome by histone proteins into a nucleoprotein complex… Expand
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TLDR
Within a simple biophysical model, the effect of electrostatic binding of H1 histone proteins on the nucleosome repeat length in chromatin is described and the importance of this non-specific histone-DNA charge-balance mechanism in regulating the positioning of nucleosomes and the degree of compaction of chromatin fibers in eukaryotic cells is underline. Expand
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