Statistical mapping of functional olfactory connections of the rat brain in vivo.

  title={Statistical mapping of functional olfactory connections of the rat brain in vivo.},
  author={Donna J. Cross and Satoshi Minoshima and Yoshimi Anzai and Jennifer A. Flexman and Bartholomew P Keogh and Yongmin Kim and Kenneth R. Maravilla},
  volume={23 4},
The olfactory pathway is a unique route into the brain. To better characterize this system in vivo, rat olfactory functional connections were mapped using magnetic resonance (MR) imaging and manganese ion (Mn2+) as a transport-mediated tracer combined with newly developed statistical brain image analysis. Six rats underwent imaging on a 1.5-T MR scanner at pre-administration, and 6, 12, 24, 36, 48, and 72 h and 5.5, 7.5, 10.5, and 13.5 days post-administration of manganese chloride (MnCl2) into… CONTINUE READING


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