Statistical kinetics of macromolecular dynamics.

  title={Statistical kinetics of macromolecular dynamics.},
  author={Joshua W. Shaevitz and Steven M. Block and Mark J. Schnitzer},
  journal={Biophysical journal},
  volume={89 4},
Fluctuations in biochemical processes can provide insights into the underlying kinetics beyond what can be gleaned from studies of average rates alone. Historically, analysis of fluctuating transmembrane currents supplied information about ion channel conductance states and lifetimes before single-channel recording techniques emerged. More recently, fluctuation analysis has helped to define mechanochemical pathways and coupling ratios for the motor protein kinesin as well as to probe the… CONTINUE READING