• DOI:10.1090/S0002-9904-1942-07641-5
• Corpus ID: 36745342

Statistical genetics and evolution

@article{Wright1942StatisticalGA,
  title={Statistical genetics and evolution},
  author={Sewall Wright},
  journal={Bulletin of the American Mathematical Society},
  year={1942},
  volume={48},
  pages={223-246}
}

• S. Wright
• Published 1 April 1942
• Biology
• Bulletin of the American Mathematical Society

Introduction. When Darwin developed the theory of evolution by natural selection, practically nothing was known of hereditary differences beyond their existence. Since 1900, a body of knowledge on the mechanism of heredity and on mutation has been built up by experiment that challenges any field in the biological sciences in the extent and precision of its results. The implications for evolution are not, however, immediately obvious. I t is necessary to work out the statistical consequences. Studies in the field of statistical genetics began shortly after the rediscovery of Mendelian heredity in 1900. Those of J. B. S. Haldane [7] and R. A. Fisher [4] have been especially important with respect to the application to evolution. My own approach to the subject came through experimental studies conducted in the U. S. Bureau of Animal Industry on the effects of inbreeding, crossbreeding and selection on populations of guinea pigs [21, 22, 23, 37] and through the attempt to formulate principles applicable to livestock breeding [19, 20, 24, 25, 13, 34]. On moving into the more academic atmosphere of the University of Chicago, I have become more directly concerned with the problem of evolution. I should note that the deductive approach, to which I shall confine myself here, involves many questions that can only be settled by observation and experimental work on natural populations and that a remarkable resurgence of interest in such work is in progress [2, 9] .