Statistical distributions of pyrosequencing

  • Yong Kong
  • Published 2009 in Journal of Computational Biology

Abstract

Pyrosequencing is emerging as one of the important next-generation sequencing technologies. We derive the statistical distributions of this technique in terms of nucleotide probabilities of the target sequences. We give exact distributions both for fixed number of flow cycles and for fixed sequence length. Explicit formulas are derived for the mean and… (More)
DOI: 10.1089/cmb.2008.0106

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