Statistical design of personalized medicine interventions: The Clarification of Optimal Anticoagulation through Genetics (COAG) trial

@inproceedings{French2010StatisticalDO,
  title={Statistical design of personalized medicine interventions: The Clarification of Optimal Anticoagulation through Genetics (COAG) trial},
  author={Benjamin French and Jungnam Joo and Nancy L. Geller and Stephen E. Kimmel and Yves D Rosenberg and Jeffrey L Anderson and Brian F. Gage and Julie A. Johnson and Jonas H. Ellenberg},
  booktitle={Trials},
  year={2010}
}
BACKGROUND There is currently much interest in pharmacogenetics: determining variation in genes that regulate drug effects, with a particular emphasis on improving drug safety and efficacy. The ability to determine such variation motivates the application of personalized drug therapies that utilize a patient's genetic makeup to determine a safe and effective drug at the correct dose. To ascertain whether a genotype-guided drug therapy improves patient care, a personalized medicine intervention… CONTINUE READING