Statistical constraints on synaptic plasticity.

  title={Statistical constraints on synaptic plasticity.},
  author={Terrence J. Sejnowski},
  journal={Journal of theoretical biology},
  volume={69 2},
The synaptic basis for learning suggested by Hebb (1949), Marr's theory (1969) for motor learning in the cerebellum, and Stent's mechanism (1973) for synaptic depression in visual cortex depend on coincidences between presynaptic and postsynaptic events. Two statistical constraints on this class of mechanisms will be examined here: the first concerns the problem of synaptic saturation from chance coincidences, and the second is the problem of random fluctuations. An alternative hypothesis for… CONTINUE READING
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