Statistical considerations in pharmacokinetic study design.

  title={Statistical considerations in pharmacokinetic study design.},
  author={J D Powers},
  journal={Clinical pharmacokinetics},
  volume={24 5},
  • J D Powers
  • Published 1993 in Clinical pharmacokinetics
Pharmacokinetic studies may generally be categorised into 3 types: (a) population-based investigations, (b) individual-based compartmental, or (c) individual-based noncompartmental research projects. Each type of study has advantages and limitations. Population-based investigations pool drug concentrations across more than 1 individual subject. From these data, estimates of pharmacokinetic parameters are calculated. NONMEM is the only computer program available to evaluate this type of… CONTINUE READING