Statistical considerations and modeling of clinical utility of tumor markers.

@article{George1994StatisticalCA,
  title={Statistical considerations and modeling of clinical utility of tumor markers.},
  author={Stephen L. George},
  journal={Hematology/oncology clinics of North America},
  year={1994},
  volume={8 3},
  pages={457-70}
}
The proper assessment of potential tumor markers in the screening, diagnosis, prognosis, and monitoring of neoplastic diseases depends on careful attention to general principles of good design and analysis of scientific studies, as well as to some specific statistical principles to avoid erroneous conclusions. Published reports on tumor markers should be evaluated critically with these principles in mind. It is well known that statistical problems exist in the medical literature despite the… CONTINUE READING

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