Statistical characterization of multiple-reaction monitoring mass spectrometry (MRM-MS) assays for quantitative proteomics

  title={Statistical characterization of multiple-reaction monitoring mass spectrometry (MRM-MS) assays for quantitative proteomics},
  author={Deepak R. Mani and Susan E. Abbatiello and Steven A. Carr},
  booktitle={BMC Bioinformatics},
Multiple reaction monitoring mass spectrometry (MRM-MS) with stable isotope dilution (SID) is increasingly becoming a widely accepted assay for the quantification of proteins and peptides. These assays have shown great promise in relatively high throughput verification of candidate biomarkers. While the use of MRM-MS assays is well established in the small molecule realm, their introduction and use in proteomics is relatively recent. As such, statistical and computational methods for the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 27 extracted citations

Mammary Stem Cells

Methods in Molecular Biology • 2015
View 5 Excerpts
Highly Influenced

ATM Kinase

Methods in Molecular Biology • 2017


Publications referenced by this paper.
Showing 1-10 of 58 references

Jardy A: What is the Best Means of Estimating the Detection and Quantification Limits of a Chromatographic Method

J Vial, KL Mapihan
Chromatographia • 2003
View 20 Excerpts
Highly Influenced

Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 4 Excerpts
Highly Influenced

A procedure for robust estimation and inference in linear regression. In Directions in Robust Statistics and Diagnosis, Part II

VJ Yohai, WA Stahel, RH Zamar
View 3 Excerpts
Highly Influenced

ROCR: visualizing classifier performance in R. Bioinformatics 2005, 21:3940-3941

T Sing, O Sander, N Beerenwinkel, T Lengauer
Mani et al. BMC Bioinformatics • 2012

Similar Papers

Loading similar papers…