Statistical aspects of the analysis of data from retrospective studies of disease.

@article{Mantel1959StatisticalAO,
  title={Statistical aspects of the analysis of data from retrospective studies of disease.},
  author={Nathan Mantel and William M. Haenszel},
  journal={Journal of the National Cancer Institute},
  year={1959},
  volume={22 4},
  pages={
          719-48
        }
}
The role and limitations of retrospective investigations of factors possibly associated with the occurrence of a disease are discussed and their relationship to forward-type studies emphasized. Examples of situations in which misleading associations could arise through the use of inappropriate control groups are presented. The possibility of misleading associations may be minimized by controlling or matching on factors which could produce such associations; the statistical analysis will then be… Expand
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