Statistical approach to estimate vaccinia-specific neutralizing antibody titers using a high-throughput assay.

@article{Kennedy2009StatisticalAT,
  title={Statistical approach to estimate vaccinia-specific neutralizing antibody titers using a high-throughput assay.},
  author={Richard B. Kennedy and V. Shane Pankratz and Eric Swanson and David Watson and H. Golding and Gregory A. Poland},
  journal={Clinical and vaccine immunology : CVI},
  year={2009},
  volume={16 8},
  pages={1105-12}
}
Because of the bioterrorism threat posed by agents such as variola virus, considerable time, resources, and effort have been devoted to biodefense preparation. One avenue of this research has been the development of rapid, sensitive, high-throughput assays to validate immune responses to poxviruses. Here we describe the adaptation of a beta-galactosidase reporter-based vaccinia virus neutralization assay to large-scale use in a study that included over 1,000 subjects. We also describe the… CONTINUE READING
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