Statistical analysis of toxicokinetic data by nonlinear regression (example: inhalation pharmacokinetics of propylene)

@article{Becka1992StatisticalAO,
  title={Statistical analysis of toxicokinetic data by nonlinear regression (example: inhalation pharmacokinetics of propylene)},
  author={Michael Becka and Hermann Maximillian Bolt and Wolfgang Urfer},
  journal={Archives of Toxicology},
  year={1992},
  volume={66},
  pages={450-453}
}
Sir, For volatile chemicals the "closed chamber technique", as recently reviewed in this journal by Filser (1992), allows investigation of kinetics of volatile substances in vivo. It is based on a closed inhalation system where during the exposure period the atmospheric concentrations of the substance are measured. The design includes experiments where the enzymatic xenobiotic-oxidizing system of the animals (cytochrome P-450) is inhibited. The concentration-time data obtained are then analyzed… CONTINUE READING

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