Statistical analysis of low molecular mass heparin nanoencapsulation.

The objective of this study was to use Box-Behnken design (BBD) to investigate the influence of formulation variables on the properties of heparin-loaded poly(lactic-coglycolic acid) (PLGA)-polymethacrylate-RLPO (E-RLPO) nanoparticles (NP) in terms of mean diameter (as size) and drug encapsulation efficiency. The NPs were prepared by the double emulsion… CONTINUE READING