Statistical analysis of drug combinations for synergism

@article{Tallarida1992StatisticalAO,
  title={Statistical analysis of drug combinations for synergism},
  author={Christopher S. Tallarida},
  journal={Pain},
  year={1992},
  volume={49},
  pages={93-97}
}
Testing a pair of drugs for synergism requires determination of the potency of the combination and comparison of this potency with that of a theoretically additive combination. The potency of a drug or of a mixture is measured as a dose (or concentration) that produces a specified level of effect such as one-half the maximum effect (E,,,). Most often this dose, denoted either D,, (for graded data) or ED50 (for quanta1 data), is obtained from an appropriate analysis of dose-effect data that… CONTINUE READING
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