Statistical analysis of a small set of time-ordered gene expression data using linear splines

@article{Hoon2002StatisticalAO,
  title={Statistical analysis of a small set of time-ordered gene expression data using linear splines},
  author={Michiel J. L. de Hoon and Seiya Imoto and Satoru Miyano},
  journal={Bioinformatics},
  year={2002},
  volume={18 11},
  pages={1477-85}
}
MOTIVATION Recently, the temporal response of genes to changes in their environment has been investigated using cDNA microarray technology by measuring the gene expression levels at a small number of time points. Conventional techniques for time series analysis are not suitable for such a short series of time-ordered data. The analysis of gene expression data has therefore usually been limited to a fold-change analysis, instead of a systematic statistical approach. METHODS We use the maximum… CONTINUE READING
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