Statistical analysis of a small set of time-ordered gene expression data using linear splines

  title={Statistical analysis of a small set of time-ordered gene expression data using linear splines},
  author={Michiel J. L. de Hoon and Seiya Imoto and Satoru Miyano},
  volume={18 11},
MOTIVATION Recently, the temporal response of genes to changes in their environment has been investigated using cDNA microarray technology by measuring the gene expression levels at a small number of time points. Conventional techniques for time series analysis are not suitable for such a short series of time-ordered data. The analysis of gene expression data has therefore usually been limited to a fold-change analysis, instead of a systematic statistical approach. METHODS We use the maximum… CONTINUE READING
33 Citations
17 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 33 extracted citations


Publications referenced by this paper.
Showing 1-10 of 17 references

A new look at the statistical model identification

  • H. Akaike
  • IEEE Trans . Automat . Contr .
  • 1974
Highly Influential
10 Excerpts

Automatic identification of a largescale field-aligned current structures

  • T. Higuchi, S. Ohtani
  • J. Geophys. Res.,
  • 2000
1 Excerpt

Automatic identification of the large scale field aligned current systems as an example of knowledge discovery from the large database ( in Japanese with English abstract )

  • T. Higuchi
  • Proceedings of the Institute of Statistical…
  • 1999
2 Excerpts

Similar Papers

Loading similar papers…