Statistical analyses of counts and distributions of restriction sites in DNA sequences.

@article{Karlin1992StatisticalAO,
  title={Statistical analyses of counts and distributions of restriction sites in DNA sequences.},
  author={Samuel Karlin and Christopher Burge and Allan M. Campbell},
  journal={Nucleic acids research},
  year={1992},
  volume={20 6},
  pages={1363-70}
}
Counts and spacings of all 4- and 6-bp palindromes in DNA sequences from a broad range of organisms were investigated. Both 4- and 6-bp average palindrome counts were significantly low in all bacteriophages except one, probably as a means of avoiding restriction enzyme cleavage. The exception, T4 of normal 4- and 6-palindrome counts, putatively derives protection from modification of cytosine to hydroxymethylcytosine plus glycosylation. The counts and distributions of 4-bp and of 6-bp… CONTINUE READING