Statistical Issues in Modeling Chronic Disease in Cohort Studies

  title={Statistical Issues in Modeling Chronic Disease in Cohort Studies},
  author={Richard J. Cook},
Observational cohort studies of individuals with chronic disease provide information on rates of disease progression, the effect of fixed and time-varying risk factors, and the extent of heterogeneity in the course of disease. Analysis of this information is often facilitated by the use of multistate models with intensity functions governing transition between disease states. We discuss modeling and analysis issues for such models when individuals are observed intermittently. Frameworks for… CONTINUE READING


Publications referenced by this paper.

The analysis of panel data under a Markov assumption

  • J Kalbfleisch, J Lawless
  • Journal of the American Statistical Association
  • 1985
Highly Influential
4 Excerpts

The design and analysis of life history studies. Statistics in Medicine (in press)

  • JF Lawless
  • 2013
Highly Influential
1 Excerpt

The empirical distribution function with arbitrarily grouped, censored and truncated data

  • B Turnbull
  • Journal of the Royal Statistical Society: Series…
  • 1976
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…