Statistical Evaluation of Vial Design Features That Influence Sublimation Rates During Primary Drying

@article{Cannon2004StatisticalEO,
  title={Statistical Evaluation of Vial Design Features That Influence Sublimation Rates During Primary Drying},
  author={Anthony Cannon and Kerryann Shemeley},
  journal={Pharmaceutical Research},
  year={2004},
  volume={21},
  pages={536-542}
}
Purpose. Understanding tubing vial design features that influence sublimation rate provides insight into the development of a more time and cost efficient lyophilization cycle. Methods. A Plackett-Burman screening experiment was initially used in evaluating multiple design features to predict those that have a statistically significant effect on sublimation rate. Sublimation rates of vials with intentional nominal and extreme dimensions were measured and directly correlated to glass vial design… CONTINUE READING
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