Statistical Controversies in Reporting of Clinical Trials: Part 2 of a 4-Part Series on Statistics for Clinical Trials.

@article{Pocock2015StatisticalCI,
  title={Statistical Controversies in Reporting of Clinical Trials: Part 2 of a 4-Part Series on Statistics for Clinical Trials.},
  author={Stuart J. Pocock and John J V McMurray and Tim J Collier},
  journal={Journal of the American College of Cardiology},
  year={2015},
  volume={66 23},
  pages={2648-2662}
}
This paper tackles several statistical controversies that are commonly faced when reporting a major clinical trial. Topics covered include: multiplicity of data, interpreting secondary endpoints and composite endpoints, the value of covariate adjustment, the traumas of subgroup analysis, assessing individual benefits and risks, alternatives to analysis by intention to treat, interpreting surprise findings (good and bad), and the overall quality of clinical trial reports. All is put in the… CONTINUE READING
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