Statistical Cluster Analysis of the British Thoracic Society Severe Refractory Asthma Registry: Clinical Outcomes and Phenotype Stability

@inproceedings{Newby2014StatisticalCA,
  title={Statistical Cluster Analysis of the British Thoracic Society Severe Refractory Asthma Registry: Clinical Outcomes and Phenotype Stability},
  author={Chris Newby and Liam G Heaney and Andrew N Menzies-Gow and Rob M. Niven and Adel H. Mansur and Christine Bucknall and Rekha Chaudhuri and John Thompson and Paul Bryan Burton and Christopher Brightling},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Severe refractory asthma is a heterogeneous disease. We sought to determine statistical clusters from the British Thoracic Society Severe refractory Asthma Registry and to examine cluster-specific outcomes and stability. METHODS Factor analysis and statistical cluster modelling was undertaken to determine the number of clusters and their membership (N = 349). Cluster-specific outcomes were assessed after a median follow-up of 3 years. A classifier was programmed to determine… CONTINUE READING