Statistical Analysis of a Method to Predict Drug-Polymer Miscibility.

  title={Statistical Analysis of a Method to Predict Drug-Polymer Miscibility.},
  author={Matthias Manne Knopp and Niels Erik Olesen and Yanbin Huang and Ren{\'e} Holm and Thomas Rades},
  journal={Journal of pharmaceutical sciences},
  volume={105 1},
In this study, a method proposed to predict drug-polymer miscibility from differential scanning calorimetry measurements was subjected to statistical analysis. The method is relatively fast and inexpensive and has gained popularity as a result of the increasing interest in the formulation of drugs as amorphous solid dispersions. However, it does not include a standard statistical assessment of the experimental uncertainty by means of a confidence interval. In addition, it applies a routine… CONTINUE READING
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