Statistical Analysis of a Gene Expression Microarray Experiment with Replication 1

  title={Statistical Analysis of a Gene Expression Microarray Experiment with Replication 1},
  author={M. Kathleen Kerr and Cynthia A. Afshari and Lee Bennett and Pierre R. Bushel and Jeanelle M. Martinez and Nigel J. Walker and Gary A. Churchill},
Common ratio-based approaches for analyzing gene expression microarray data do not provide a framework for handling replication, although replication is clearly desirable for this noisy data. In contrast, replication fits naturally into analysis of variance (ANOVA) methods. We use ANOVA to analyze data from a microarray experiment to compare gene expression in drug-treated and control cells lines. We discuss issues that commonly arise in the analysis of microarray data, and present practical… CONTINUE READING

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