Statins reduce vascular inflammation in atherogenesis: a review of underlying molecular mechanisms.

@article{Liberale2020StatinsRV,
  title={Statins reduce vascular inflammation in atherogenesis: a review of underlying molecular mechanisms.},
  author={Luca Liberale and Federico Carbone and Fabrizio Montecucco and Amirhossein Sahebkar},
  journal={The international journal of biochemistry \& cell biology},
  year={2020},
  pages={
          105735
        }
}
Statins and Inflammation
Chronic inflammation has been recognized as one of the most important pathophysiological mechanisms’ initiation and progression of atherosclerosis. Statins belong to most successful therapeutic
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References

SHOWING 1-10 OF 86 REFERENCES
Pleiotropic Effects of Statins on the Cardiovascular System
TLDR
This review examines some of the currently proposed molecular mechanisms for statin pleiotropy and discusses whether they could have any clinical relevance in cardiovascular disease.
Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia
TLDR
In primary hypercholesterolemia, simvastatin treatment reduced platelet activation and subclinical inflammation and improved endothelial dysfunction and LDL-cholesterol levels were the major correlate of platelet reactivity.
The Role of Inflammation in Cardiovascular Outcome
TLDR
The pathophysiological role of innate immune response in the cardiovascular (CV) disease outcomes is updated, particularly focusing on coronary atherosclerosis and heart failure, to improve the determination of the prognostic relevance of inflammatory biomarkers on clinical CV outcome.
Targeting Inflammation in Primary Cardiovascular Prevention.
TLDR
Conflicting results emerged from clinical trials, emphasized the need to characterize the inflammatory profile of the patients, to minimize the heterogeneity of study populations and to clarify the true value of CRP as specific biomarker of atherosclerosis-related inflammation.
Statins Induce the Accumulation of Regulatory T Cells in Atherosclerotic Plaque
TLDR
Simvastatin improved the quantity and suppressive function of Tregs in ACS patients and played an important role in modulating the balance between antiinflammatory and proinflammatory subsets of T cells.
Statins as regulators of redox signaling in platelets.
TLDR
The antiplatelet effects of statins could turn useful in clinical settings where the clinical efficacy of aspirin and other antiplatelets drugs are still uncertain.
The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion.
TLDR
The improvement in endothelium-dependent vasomotion with cholesterol-lowering and antioxidant therapy may have important implications for the activity of myocardial ischemia and may explain in part the reduced incidence of adverse coronary events that is known to result from cholesterol- Lowering therapy.
New Therapies Targeting apoB Metabolism for High-Risk Patients with Inherited Dyslipidaemias: What Can the Clinician Expect?
TLDR
Monoclonal antibodies against PCSK9 have an excellent safety profile and may be indicated not only in heterozygous FH, but also in statin-intolerant patients and those with other inherited dyslipidemias, such as familial combined hyperlipidaemia and familial elevation in Lp(a).
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