Statins reduce vascular inflammation in atherogenesis: a review of underlying molecular mechanisms.

@article{Liberale2020StatinsRV,
  title={Statins reduce vascular inflammation in atherogenesis: a review of underlying molecular mechanisms.},
  author={Luca Liberale and Federico Carbone and Fabrizio Montecucco and Amirhossein Sahebkar},
  journal={The international journal of biochemistry \& cell biology},
  year={2020},
  pages={
          105735
        }
}
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31 Citations
Background Citations
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31 Citations

Statins and Inflammation
Chronic inflammation has been recognized as one of the most important pathophysiological mechanisms’ initiation and progression of atherosclerosis. Statins belong to most successful therapeutic…
Cytokines as therapeutic targets for cardio- and cerebrovascular diseases
TLDR
The state of knowledge regarding the modulatory role of cytokines on atherosclerosis, myocardial infarction, and stroke is summarized and evidence from clinical trials specifically targeting cytokines is discussed.
Effects of statins on myocarditis: A review of underlying molecular mechanisms.
Recent efforts in drug discovery on vascular inflammation and consequent atherosclerosis
TLDR
The therapeutic and nutraceutical approaches represent useful tools to treat or prevent different phases of vascular inflammation, in particular the pharmacological approach should be used in advanced phases characterized by clinical signs of vascular disease, whilst the nutr pharmaceutical approach may represent a promising preventive strategy to preserve the integrity of the endothelial tissue.
The role of statins in the differentiation and function of bone cells
TLDR
Earlier studies have shown that statins cause in vitro and in vivo osteogenic differentiation, which decreases the risk of developing atherosclerosis and its acute complications, such as acute myocardial infarction and ischaemic stroke.
It's All About the Inflammation
TLDR
The data suggest that inflammation is an important part of the atherosclerotic process and therapies that target inflammation are beneficial in terms of a reduction in cardiovascular events.
Animal Models of Atherosclerosis–Supportive Notes and Tricks of the Trade
TLDR
This review distill old notions with emerging concepts into a contemporary understanding of vascular disease models to aid the development of cardiovascular disease diagnostics and therapeutics of the future.
Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics
TLDR
Both traditional and novel inflammatory biomarkers related to components of the innate and adaptive immune system that may mirror the progression or phases of atherosclerotic inflammation/lesions are clarified.
Effects of statins on brain tumors: a review.
Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis
TLDR
It is suggested that defective mitophagy promoted by mutations in mitochondrial DNA can cause innate immunity disorders leading to chronification of inflammation.
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