Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis.

@article{Ifergan2006StatinsRH,
  title={Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis.},
  author={Igal Ifergan and Karolina Wosik and Romain Cayrol and Hania K{\'e}bir and Chantale Auger and Monique Boucherville Bernard and Alain Bouthillier and Robert A. Moumdjian and Pierre Duquette and Alexandre Prat},
  journal={Annals of neurology},
  year={2006},
  volume={60 1},
  pages={
          45-55
        }
}
OBJECTIVE Dysregulation of the blood-brain barrier (BBB) and transendothelial migration of immune cells are among the earliest central nervous system changes partaking in lesion formation in both multiple sclerosis (MS) and its early clinical form, the clinically isolated syndrome. Evidence for the anti-inflammatory effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors within the central nervous system arose from studies demonstrating that statins improve clinical signs in the… CONTINUE READING
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