Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.

@article{Tamboli2010StatinsPT,
  title={Statins promote the degradation of extracellular amyloid \{beta\}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.},
  author={Irfan Y. Tamboli and Esther Barth and Leonie Christian and Martin Siepmann and Surendra Kumar and Sandesh K. Singh and Karen Tolksdorf and Michael T Heneka and Dieter L{\"u}tjohann and Patrick Wunderlich and Juergen Walter},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 48},
  pages={
          37405-14
        }
}
Epidemiological studies indicate that intake of statins decrease the risk of developing Alzheimer disease. Cellular and in vivo studies suggested that statins might decrease the generation of the amyloid β-peptide (Aβ) from the β-amyloid precursor protein. Here, we show that statins potently stimulate the degradation of extracellular Aβ by microglia. The statin-dependent clearance of extracellular Aβ is mainly exerted by insulin-degrading enzyme (IDE) that is secreted in a nonconventional… CONTINUE READING
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