Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype.

@article{Meroni2001StatinsPE,
  title={Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype.},
  author={Pier Luigi Meroni and Elena Raschi and Cinzia Testoni and Angela Tincani and Genesio Balestrieri and Raffaella Molteni and Munther A. Khamashta and Elena Tremoli and Marina Camera},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 12},
  pages={2870-8}
}
OBJECTIVE To investigate the ability of statins, the inhibitors of the hydroxymethylglutaryl-coenzyme A reductase enzyme, to affect endothelial cell activation induced by anti-beta2-glycoprotein I (anti-beta2GPI) antibodies in vitro. METHODS Human umbilical vein endothelial cell (HUVEC) activation was evaluated as U937 monocyte adhesion, E-selectin, and intercellular adhesion molecule I (ICAM-1) expression by cell enzyme-linked immunosorbent assay and as interleukin-6 (IL-6) messenger RNA… CONTINUE READING

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