Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators.

@article{Kizu2004StatinsII,
  title={Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators.},
  author={Akane Kizu and Atsushi Shioi and Shuichi Jono and Hidenori Koyama and Yasuhisa Okuno and Yoshiki Nishizawa},
  journal={Journal of cellular biochemistry},
  year={2004},
  volume={93 5},
  pages={1011-9}
}
Although lipid-lowering therapy with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) decreases the progression of coronary artery and aortic valve calcification, the mechanism of action of these drugs to inhibit the calcification process remains unclear. In this study, we investigated the effect of statins such as cerivastatin and atorvastatin on vascular calcification by utilizing an in vitro model of inflammatory vascular calcification. Cerivastatin and atorvastatin dose… CONTINUE READING
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