Statins for the treatment of dementia.

  title={Statins for the treatment of dementia.},
  author={Bernadette McGuinness and John O'Hare and David Craig and Roger Bullock and Reem Malouf and Peter Passmore},
  journal={The Cochrane database of systematic reviews},
BACKGROUND The use of statin therapy in established Alzheimer's disease (AD) or vascular dementia (VaD) is a relatively unexplored area. In AD ss-amyloid protein (Ass) is deposited in the form of extracellular plaques and previous studies have determined Ass generation is cholesterol dependent. Hypercholesterolaemia has also been implicated in the pathogenesis of VaD. Due to the role of statins in cholesterol reduction it is biologically plausible they may be efficacious in the treatment of AD… CONTINUE READING
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