Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase.


BACKGROUND We have previously shown that inhaled corticosteroids activate indoleamine 2, 3-dioxygenase (IDO) activity through increased IL-10 secretion. Statins might enhance the anti-inflammatory effects of corticosteroids. OBJECTIVE In a double-blind study we added simvastatin to patients with mild asthma receiving a low dose of inhaled budesonide and… (More)
DOI: 10.1016/j.jaci.2010.08.005

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