Statins can modulate effectiveness of antitumor therapeutic modalities.

  title={Statins can modulate effectiveness of antitumor therapeutic modalities.},
  author={Marek Jak{\'o}bisiak and Jakub Goląb},
  journal={Medicinal research reviews},
  volume={30 1},
Despite significant, frequently very strong, antiproliferative and tumoricidal effects of statins demonstrated in vitro, their antitumor effects in animal models are modest, and their efficacy in clinical trials has not been proven. As such, statins seem unlikely to be ever regarded as antitumor agents. However, statins are regularly taken by many elderly cancer patients for the prevention of cardiovascular events. Owing to their pleiotropic effects in normal and tumor cells, statins interact… CONTINUE READING