Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.

@article{Maeda2003StatinsAV,
  title={Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.},
  author={Toyonobu Maeda and Tetsuya Kawane and Noboru Horiuchi},
  journal={Endocrinology},
  year={2003},
  volume={144 2},
  pages={681-92}
}
Statins such as simvastatin are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that inhibit cholesterol synthesis. We presently investigated statin effects on vascular endothelial growth factor (VEGF) expression in osteoblastic cells. Hydrophobic statins including simvastatin, atorvastatin, and cerivastatin-but not a hydrophilic statin, pravastatin-markedly increased VEGF mRNA abundance in nontransformed osteoblastic cells (MC3T3-E1). Simvastatin (10(-6) M) time-dependently… CONTINUE READING
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