Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.

@article{Kodach2011StatinsAT,
  title={Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.},
  author={Liudmila L. Kodach and Rutger J. Jacobs and Philip W Voorneveld and Manon E. Wildenberg and Henricus W Verspaget and Tom van Wezel and Hans Morreau and Daniel W. Hommes and Maikel P Peppelenbosch and Gijs van den Brink and James C.H. Hardwick},
  journal={Gut},
  year={2011},
  volume={60 11},
  pages={1544-53}
}
BACKGROUND Promoter hypermethylation is an important and potentially reversible mechanism of tumour suppressor gene silencing in cancer. Compounds that demethylate tumour suppressor genes and induce differentiation of cancer cells, but do not have toxic side effects, would represent an exciting option in cancer therapy. Statins are cholesterol-lowering drugs with an excellent safety profile and associated with a reduced incidence of various cancers including colorectal cancer (CRC). The authors… CONTINUE READING
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