Statins attenuate polymethylmethacrylate-mediated monocyte activation.

  title={Statins attenuate polymethylmethacrylate-mediated monocyte activation.},
  author={Alan J. Laing and John Patrick Dillon and Kevin James Mulhall and Jian Wang and Anthony J McGuinness and Paul H Redmond},
  journal={Acta orthopaedica},
  volume={79 1},
BACKGROUND Periprosthetic osteolysis precipitates aseptic loosening of components, increases the risk of periprosthetic fracture and, through massive bone loss, complicates revision surgery and ultimately is the primary cause for failure of joint arthroplasty. The anti-inflammatory properties of HMG-CoA reductase inhibitors belonging to the statin family are well recognized. We investigated a possible role for status in initiating the first stage of the osteolytic cycle, namely monocytic… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 34 references

Mitogen-activated protein (MAP) kinases mediate PMMA-induction of osteoclasts.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2003

Efficacy of etanercept for wear debris-induced osteolysis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2001

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