Statins and the vascular endothelial inflammatory response.

  title={Statins and the vascular endothelial inflammatory response.},
  author={John Greenwood and J. Christian Mason},
  journal={Trends in immunology},
  volume={28 2},
Statins reduce cholesterol synthesis and are widely used for the treatment of hyperlipidaemia and ischaemic heart disease. Besides their cholesterol-lowering effects, statins also possess broad immunomodulatory and anti-inflammatory properties. Vascular endothelial cells have a crucial role in the pathogenesis of inflammatory disease, and, alongside leukocytes and antigen-presenting cells, represent a key cellular target for statin therapy. Recent studies investigating how these drugs modify… CONTINUE READING
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