Statins and the risk of colorectal cancer.

  title={Statins and the risk of colorectal cancer.},
  author={Jenny N. Poynter and Stephen B. Gruber and Peter D. R. Higgins and Ronit Almog and Joseph D. Bonner and Hedy S. Rennert and Marcelo Low and Joel K. Greenson and Gadi Rennert},
  journal={The New England journal of medicine},
  volume={352 21},
BACKGROUND Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and effective lipid-lowering agents. Statins inhibit the growth of colon-cancer cell lines, and secondary analyses of some, but not all, clinical trials suggest that they reduce the risk of colorectal cancer. METHODS The Molecular Epidemiology of Colorectal Cancer study is a population-based case-control study of patients who received a diagnosis of colorectal cancer in northern Israel between 1998 and 2004… 

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