Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins.

@article{Roy2011StatinsAP,
  title={Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins.},
  author={Mohana Roy and Hsing-Jien Kung and Paramita M. Ghosh},
  journal={American journal of cancer research},
  year={2011},
  volume={1 4},
  pages={542-61}
}
Prostate cancer (PCa) is initially regulated by androgens, such as testosterone and dihydrotestosterone, which regulates cell proliferation and survival by activating the androgen receptor (AR), but later progresses to an aggressive, metastatic, androgen-independent stage for which, currently, there is no cure. Here, we argue that prevention of PCa progression is a better strategy compared to trying to cure the disease once it has already progressed. Statins inhibit the mevalonate pathway, thus… CONTINUE READING

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