Statins and New-Onset Diabetes Mellitus: LDL Receptor May Provide a Key Link

@article{Yu2017StatinsAN,
  title={Statins and New-Onset Diabetes Mellitus: LDL Receptor May Provide a Key Link},
  author={Q. Yu and Y. Chen and Cang-Bao Xu},
  journal={Frontiers in Pharmacology},
  year={2017},
  volume={8}
}
Numerous studies have noted that populations treated with statins have increased risk for new-onset diabetes mellitus; however, the underlying molecular mechanisms are not fully understood. Interestingly, familial hypercholesterolemia (FH) patients with mutations in the low-density lipoprotein receptor (LDLR) gene are protected against diabetes mellitus (DM), despite these patients being subjected to long-term statin therapy. Since the common pathway between FH and statin therapy is LDLR… Expand
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