Statins Inhibit the Proliferation and Induce Cell Death of Human Papilloma Virus Positive and Negative Cervical Cancer Cells

@inproceedings{Crescencio2009StatinsIT,
  title={Statins Inhibit the Proliferation and Induce Cell Death of Human Papilloma Virus Positive and Negative Cervical Cancer Cells},
  author={Mar{\'i}a Elena Crescencio and Emma Isabel Garc{\'i}a Rodr{\'i}guez and Araceli Paez and Felipe Mass{\'o} and Luis Felipe Monta{\~n}o and Rebeca L{\'o}pez-Marure},
  booktitle={International journal of biomedical science : IJBS},
  year={2009}
}
Statins, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, have anti-tumoral effects on multiple cancer types; however, little is known about their effect on cervical cancer. We evaluated the effect on proliferation, cell cycle, oxidative stress and cell death of three statins on CaSki, HeLa (HPV(+)) and ViBo (HPV(-)) cervical cancer cell lines. Cell proliferation was assayed by crystal violet staining, cell cycle by flow cytometry and cell death by annexin-V… CONTINUE READING

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